NIH Clinical Center Photograph
NIH Clinical Center
Do you have unmanageable pain at or below the level of the chest due to advanced cancer?

If so, you may qualify for a study of an investigational treatment for severe cancer pain. The study (#09-D-0039) is being conducted by researchers at the National Institutes of Health, (National Institute of Neurological Disorders and Stroke and National Institute of Dental and Craniofacial Research) in Bethesda, Maryland. The treatment involves placing a needle in the low back and injecting an experimental drug called resiniferatoxin (RTX) into the fluid surrounding the spinal cord. The drug RTX is related to capsaicin, the active ingredient in hot peppers. It relieves pain by selectively destroying nerves that transmit pain information. The purposes of this study are to determine the safety of the new treatment and to see whether the treatment reduces pain and the need for pain medication. Preliminary research in animals has shown that RTX can reduce pain and appears to be safe. This is the first time RTX will be given into the spinal fluid in people.

To learn more about the study and the study personnel, click on the links to the left. If you are interested in participating or would like more information, please contact us.